Mayo Analysis

by Rant on August 12, 2008 · 18 comments

in Doping in Sports, Iban Mayo

If you’re a regular reader of this blog, no doubt you’ve already heard about the Court of Arbitration for Sport’s decision in the case of Iban Mayo. A CAS panel issued a ruling suspending the Spanish cyclist from competition for two years, based on a positive test for EPO during the 2007 Tour de France. Mayo’s suspension will expire at the end of July 2009, meaning that if he does resume his cycling career, it will be 2010 at the very earliest before he can participate in the Super Bowl of cycling. (Assuming the ASO lets Mayo’s team compete with the Spaniard in the mix.)

When the CAS issued their decision earlier today, they posted the panel’s written opinion in French. Over at Trust But Verify, you can read a machine translation of the today’s ruling. I’ve only had a chance to glance through the document (it’s 33 pages in the original PDF version). Nevertheless, I’ve found a few interesting tidbits.

I’ve been under the impression that with the urine EPO test that WADA requires a separate lab to do the confirmation tests (a/k/a the B sample). Reading through the panel’s ruling, I find that either I’m under the wrong impression, or that the actual practice of EPO testing is conducted differently than WADA’s requirements. It turns out that for each test run on Mayo’s sample, the data resulting from that test was forwarded on to a different laboratory to double-check the analysis and interpretation.

The tests conducted at LNDD were verified by the WADA lab in Lausanne, Switzerland. The lab in Ghent, Belgium, where the original B sample analysis was performed, forwarded their results to the Australian Anti-Doping lab in Sydney. And this is where things begin to get interesting. Mayo’s A sample was declared to be a positive test result, triggering the B sample testing.

But when the Ghent lab tested Mayo’s B sample, their results were inconclusive. The lab in Sydney concurred, adding that they suggested doing further tests on the B sample — if enough of the B sample existed to do such testing. From the panel’s write-up, it’s not clear who the Sydney lab thought should do that additional testing.

The big bone of contention between the UCI and Mayo/RFEC (the Spanish Cycling Federation) was whether or not the additional B sample testing should be allowed. Due to the results reported by the Ghent lab, the RFEC and Mayo both believe that should be the end of the road. The UCI disagreed. And now, the CAS has backed up the UCI on that point. Further testing is allowed.

This establishes an interesting precedent. And, as you learn from an interview I’ll be publishing soon (I hope), there is such a thing as precedent in the CAS system. Even if we’ve been told otherwise. The precedent this case establishes is that — as long as the testing lab believes they have enough of a sample to work with, they can re-do the B sample tests as much as they like. Further, B samples can be shipped to different labs to conduct that work, if necessary. (If I understood the ruling correctly, the Ghent lab didn’t believe they could do the additional testing on the small amount of Mayo’s B sample that remained. They suggested that maybe LNDD could do that testing, instead.)

On the surface, as the panel writes the decision, it appears pretty logical. Sometimes tests get messed up and need to be re-run. The WADA rules, the panel says, allows for such testing. And in Mayo’s case, they believe that the inconclusive nature of the Ghent results allows for the additional work. Mayo tried to argue that he owned the samples and that he refused to allow the additional testing. That argument got slapped down, as did other arguments he and his side presented.

What’s also interesting about the case is the clear divergence of opinions and results. For both the A sample and B sample analyzed by LNDD, the Lausanne lab’s report on the data says that it is a clear indication of the use of EPO. In the Ghent testing, the Sydney lab’s opinion was that it was unclear and warranted further testing. To the CAS panel, the additional testing was within the “letter and spirit” of the UCI anti-doping regulations and the ISL.

Perhaps. But the precedent that’s been set is that a lab need only declare results inconclusive in order to keep testing, in the hopes of confirming their initial result. Sometimes that may be true. But it’s also a loophole that’s rife with the possibility of abuse. And, as has been noted recently, the more you test, the more likely it is that you’ll eventually get the result you want. If we’re going to allow multiple testing of the B sample by the anti-doping labs, shouldn’t the athletes also have a right to have the samples tested again and again. What if, in that circumstance, a contradictory result came up. Should the athlete then be acquitted of his/her doping violation?

What’s needed here is a set of clear, consistent and easy to understand rules. They should spell out under exactly what circumstances additional tests can be run on a B sample. If those circumstances aren’t met, no additional testing should be allowed. And if the labs have a right to retest, the rules should also address circumstances under which an athlete could demand further testing, as well.

Since this issue was the big bone of contention between the sides in the Mayo case, I think it’s fair to say that the rules on this issue were not crystal clear before today’s ruling was announced. In scanning the ruling, it appears to only address when an anti-doping lab can do additional testing. It will be quite a while (if ever) before any rules are established regarding whether an accused athlete can ask for further analysis of a B sample.

Interestingly, the panel started Mayo’s suspension from the day he was suspended (fired?) by Saunier Duval. Differing CAS panels can issue differing opinions on the same subject. Imagine if that standard had been applied to Floyd Landis. He’d just be returning to the pro peloton right about now, rather than having to sit out another five months. Nothing like consistency in at the “Supreme Court of Sport,” eh? Problem is, there’s no central tribunal that can correct contradictory CAS rulings. That’s a shame, because that is a serious weakness of the current system. But more on that when I finish writing up that interview I mentioned earlier. Which, I hope, will be within the next few days.

William Schart August 13, 2008 at 7:16 am

I wonder what would have happened if the Ghent lab had said their test was negative instead of “inconclusive”. We have had some discussion of what criteria are used to establish a positive result, but have sort of assumed that if it isn’t positive for drugs, then it must be negative. But now this isn’t so; we have a third possibility “inconclusive”. But we have no rules or standards or criteria for what constitutes an “inconclusive” result. Would UCI/WADA have attempted to shop Mayo’s testing around if Ghent had said the result was negative?

We also have CAS to all intents and purposes making rules. The new standard now simply meeting the “spirit and intent” of the regulations, and “honest mistakes” (whatever those might be) are OK.

All this seems to play along with the idea that athletes who cheat by use of PEDs are somehow lower than low and such cheating threatens the very existence of sport. I am not sure that this is necessary true.

fmk August 13, 2008 at 8:08 am

AFAIK, WADA prefers suspensions to start from the date from which a rider accepts his punishment. See the WADA Code, article 10. So eg St David of the Slipstream saw his suspension pushed back to the date of his arrest, because he accepted his fault so quickly after that. The reason Landis’s ban wasn’t pushed back to his sacking from Phonak in September was that he didn’t accept he was out of competition until the following January. If he’d accepted that earlier, he’d be back racing earlier.

Was Mayo fired or suspended? Well they were still paying him, so he clearly wasn’t fired. He was suspended on July 31st, pending the outcome of the B test. When that was inconclusive, Saunier Duval decided to keep him suspended pending the CAS decision.

On where the B sample should be tested — you need to refer to WADA’s International Standard For Laboratories, the version which was in force when this happened (V4). Specially, you’re looking at article 5.2.4.3.2.2 which states that the B sample should be tested by the same Lab as did the A test. However, the UCI’s own rules allow for the B sample to be analysed elsewhere (Part IV, Anti-Doping, Chapter VII, s195).

On whether Ghent / Sydney returned a result on the B sample — I think they didn’t. Sydney certainly ruled themselves out of returning a result citing stability, which is a requirement in determining a result. Obviously the B sample can be tested as many times as is necessary in order to return a result, but the point is, once a result is actually returned, that’s it, whether it’s positive or negative. Again, the UCI’s own rules here should also be looked at — they specifically refer to the B sample being negative, not the B sample supporting the A sample.

Rant August 13, 2008 at 9:10 am

fmk,
Thanks for the references.
I think in Landis’ case, he and his lawyers felt that accepting the suspension would be an admission of guilt, which at that point they weren’t willing to do. It was a bit of gamesmanship on the part of the AFLD that finally forced him to agree not to compete in France during 2007. From my understanding, WADA’s rules are that an athlete’s punishment starts when he/she is suspended from competition. One could argue that Landis had a de-facto suspension starting on August 5th, 2006. After that date, no sane race promoter would allow him to race lest the other cyclists be punished for racing against him (which USA Cycling threatened to do when Tyler Hamilton raced in some training races during his days in the wilderness). And, after that date, no team would touch him.
Certainly no ProTour team bound by the ProTour code of ethics would have hired him. So, yes, Landis didn’t accept any sort of suspension until January 2007, and that’s when both arbitration panels chose to start his two years’ punishment. But the reality is a bit different. He hasn’t been able to compete for more than two years now.
Now, one can argue that he would have been better off accepting a provisional suspension. And at this point, given how things have turned out, I’d have to agree. In hindsight,that would have been the smartest choice. Had he done so, he’d be able to compete now. But on a personal level, had he done so, he’d have been admitting guilt, which he was (and I believe still is) loath to do.
On the B samples, in general that’s correct, the same lab does both analyses. I thought I saw a WADA technical document that required the confirmation of a urine EPO test result by a different lab. That makes the urine EPO test the oddball test, as for everything else, the confirmation is done by the same lab, as the rules you cite require. What appears to be the practice for the urine EPO test is that the data is farmed out to another lab to see if they agree with the interpretation.
I think your comment about returning a result on the part of Ghent/Sydney is spot on, as I read the panel’s decision. The CAS panel is saying that in the absence of a result, the UCI is free to have the sample tested until either there is no more to be tested, or a result is determined, whichever comes first.
But all that begs the question: Is a determination of no result in fact a “result”? For this panel, the answer is no. To take a cynical point of view, I can still see how things could be manipulated to get the desired result, by declaring that no determination had been reached on various iterations of a B sample test. If an athlete challenged results determined in this way, perhaps he or she would win in arbitration. But that’s an expensive and time-consuming process, and there’s no guarantee that a lab’s findings would be thrown out for pursuing the answer they wanted rather than the answer they got the first time.

Thomas A. Fine August 13, 2008 at 10:06 am

I think the response from WADA et al depends on the size of the fish. If you’re a little fish, they’re not going to waste the time and money, they’ll call it inconclusive and your done. And if you’re a little fish and you get sanctioned but want your day in court, there’s a chance you can get a fair hearing (cf Landaluze).

But if you’re a big fish, WADA will turn any irregularity into an ironclad positive, and defend that positive to their dying breath. And when it’s time to circle the wagons, WADA can be happy to know that CAS’es wagons will join them in the circle.

tom

Jean C August 13, 2008 at 1:01 pm

Manipulation of people is risky, especially when a lot of people are involved, a lot of different lab, different culture.
So difficult to believe the existence of a corrupted coalition

Rant August 13, 2008 at 1:17 pm

Jean,
I’m not suggesting manipulation in some sort of grand conspiracy kind of way. I’m thinking more of the kind of situation such as a high-profile case where the results have been leaked to the media inappropriately. In that case, a group within a lab may feel under pressure to replicate their original findings for fear of the uproar that might develop if the second test contradicts the original.
Knowing that they have the opportunity to continue retesting the B sample until they get the results they want (by simply calling the results they don’t want “inconclusive”), a person or a few people could take advantage of the loophole and keep on testing until they get the desired result. The phenomenon goes by many different names. It doesn’t always occur with malice toward the “victim” even. It’s often called CYA (cover your arse).
Even within the most ethical of organizations and institutions, there’s always a few who don’t quite live up to the overall standards.

Tomas T August 13, 2008 at 1:47 pm

All this talk about ‘inconclusive’, without explaining how, annoys me

The only way you can reasonably call a test ‘inconclusive’ is if the data shows that the lab mucked it up (in which case a re-test is quite reasonable).

If the test is properly done and isn’t positive, then it must be negative. No way around it. Is there anything in the docs that suggests that the Ghent test was not properly/successfully caried out?

Rant August 13, 2008 at 2:21 pm

Tomas,
I’ve only had a brief amount of time to look through the translation of the Mayo decision (not much else is available in terms of documentation), here’s the machine translation of part of what the panel said about the Ghent/Sydney testing:

21. On 23 August 2007, the laboratory of Ghent issued a certificate of analysis of sample B (hereinafter: analysis B1), in which reference was made to the opinion of a second laboratory: “The opinion of the second laboratory for the evaluation of the results indicates that the results of the analysis for the rhEPO are inconclusive. ” This is a second laboratory namely the ‘Australian Sports Drug Testing Laboratory in Sydney.
22. The report issued by the laboratory, whose findings are included in the certificate analysis issued by the laboratory of Ghent, was essentially that the analytical results B1 was not conclusive, especially because the stability of the sample had not been established. The laboratory in Sydney recommended to repeat the analysis of sample B, if it still contains enough urine for a further analysis…

At least one reason the Ghent lab calls their testing inconclusive appears to be a concern over whether the stability of the sample was established. There is probably more within the CAS panel’s ruling, but it won’t be as complete a picture as all the documentation for the Landis case. The lack of complete information is frustrating. That’s at least due in part to the fact that neither Mayo nor the CAS has gone “wiki”.

Jean C August 14, 2008 at 2:00 am

From what I recall of the report is :
the Ghent lab is still confident that Mayo’ sample was not without rEPO. Their diffulties was to get the correct measure, like a car speeding at 100km/h where the limit is 50. Even without a measure most of the people seeing the car can say that the car was speeding.

fmk August 14, 2008 at 4:18 am

Thomas – you say WADA will do this, and WADA will do that. The fact is though WADA have no role in the prosecution of the offence – it’s the UCI who were determined to get Mayo. After the Giro non-negative, the UCI decided they were going to nail him, and the UCI nailed him. You can see how determined the UCI were to get him by the hoops they’ve jumped through on this test.

Tomas – The inconclusive was explained – the stability criteria had not been met. Read the rules on how a result is to be determined.

Rant – the results of the test are confirmed by another lab, but only on the basis of a review of the documentation / results, not by carrying out the test again.

fmk August 14, 2008 at 6:37 am

BTW Rant, on testing the B sample at a second lab. Are you familiar with the case of the Irish equestrian rider, Cian O’Connor, and what happened his B sample when it was sent to a second lab to be tested following his Athens positive? It was like something out of a Dick Francis thriller.

Rant August 14, 2008 at 7:16 am

fmk,
Agreed on the confirmation by the second lab. That’s very clear from the information in the CAS panel’s ruling.
I’m only acquainted with the basics of the O’Connor story. If you’ve got a link to articles or sites where I can learn more, I’d be happy to take a look.

fmk August 14, 2008 at 7:58 am

The long and the short is the B sample (urine) went missing on its way to the lab in Newmarket. Someone went up to the van delivering it, said they were from the lab, signed for it and rode off never to be seen again. (If McQuaid’s mafia comments are to be credited, you’d imagine Mayo’s sample could similarly have been intercepted enroute to Ghent no?) With the B sample missing, the equine federation – FEI – decided they could use the blood B sample to confirm the A urine result. I don’t think even the UCI have thought to cross samples yet just to get a result. In the end O’Connor accepted the result, lost his medal and was out of competition for three whole months. Would have loved to see that case going to the CAS. Not to see O’Connor get his medal back (that wouldn’t have been just) but just to get a decision on the process used. Really he should have been treated the same as Hamilton.

Not sure about links – the reporting tended to be biased for and against because O’Connor’s godfather is the media mogul Tony O’Reilly and his media group sponsored O’Connor’s horse.

Rant August 14, 2008 at 10:29 am

Now there’s an interesting and intriguing story, straight out of a thriller! That kind of stuff, apparently, doesn’t just happen in books or movies. The FEI used a very novel approach to confirming the A sample. Apparently it stood muster during the whole arbitration process, but it seems pretty odd, nonetheless. I’d have to agree. Guilty or not, O’Connor should have been treated the same as Hamilton. No urine B sample to analyze, no case.
Of course, I wonder if that was just the thought process of the person(s) responsible for the B sample’s disappearance. And it certainly raises intriguing questions of who might have been behind the disappearance. Interesting connections with who was sponsoring O’Connor’s horse, too.

fmk August 14, 2008 at 11:45 am

Rant – are you suggesting the Murphia might have been involved? Perish the thought! McQuaid counted us as one of the Anglo-Saxon nations and not prone to such things. But then a made man like him would say that, wouldn’t he?

I wrote a piece about O’Connor for a site I was involved in back then, it’s a fascinating story, no doubt about it. The whole world of equestrianism – and not just racing – is well worth looking into. What got revealed didn’t just involve doping the horses, but also beating their legs to make them scared of hitting fences when jumping.

If you Google – “cian o’connor” newmarket “waterford crystal” – you should get the skinny on the story. The Telegraph version is pretty good. That search also threw up this story – http://archives.tcm.ie/irishexaminer/2005/11/18/story265056172.asp – about another equine sample going missing, this time from within the lab, and a further sample that had its seal broken by the time it reached the lab. Clearly there are other sports with much worse doping problems than cycling and not even pretending to do something about it like the UCI historically has. Whenever you think LNDD is dodgy, just remember how dodgy it really *could* be, compared to other labs 🙂

Rant August 14, 2008 at 2:48 pm

fmk,
Thanks. There are a number of interesting stories I’ve found following that Google search. Looks like something to include in the Afterward for my book, and into a future revision.

William Schart August 14, 2008 at 3:40 pm

How about Doping II? Or The Son of Doping? Or maybe And the Horse You Rode in on?

Rant August 16, 2008 at 3:35 pm

William,
Those are all good titles for either the Afterword or the next book. If the next one is the sequel to Dope: The Book. … And the Horse You Rode In On is especially good. 🙂

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